RT Journal
A1 Strongwater SL, Galvanek EG, Stoff JS
T1 COntrol of hypertension and reversal of renal failure in undifferentiated connective tissue disease by enalapril
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1989
FD March 1
VO 149
IS 3
SP 582
OP 585
DO 10.1001/archinte.1989.00390030070013
UL http://dx.doi.org/10.1001/archinte.1989.00390030070013
AB • Activation of the renin angiotensin system is important in the development of accelerated hypertension and progression to acute renal failure in scleroderma and undifferentiated connective tissue disease. Inhibition of angiotensin-converting enzyme activity may effectively control blood pressure and ameliorate renal insufficiency. To our knowledge, we describe the first reversal of dialysis-dependent renal insufficiency by enalapril maleate and recovery and maintenance of near-normal renal function in a patient suffering from undifferentiated connective tissue disease with sclerodermatous features. The pathophysiologic mechanisms and long-term treatment implications with angiotensin-converting enzyme inhibitors in this setting are discussed.(Arch Intern Med 1989;149:582-585)