RT Journal
A1 Blake JW, Solangi KB, Herman MV, Goodman AA, Meggs LG
T1 LEft ventricular response to exercise and autonomic control mechanisms in end-stage renal disease
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1989
FD February 1
VO 149
IS 2
SP 433
OP 436
DO 10.1001/archinte.1989.00390020127027
UL http://dx.doi.org/10.1001/archinte.1989.00390020127027
AB • Left ventricular (LV) function during rest and during exercise was evaluated in patients with end-stage renal disease (ESRD) in whom other causes of LV dysfunction were eliminated through rigid selection criteria. Autonomic function was also assessed in these patients with Valsalva's maneuver and plasma catecholamine determinations. Echocardiography and radionuclide ventriculography in the group with ESRD revealed no abnormalities of LV wall motion or ejection fraction. During graded exercise, patients with ESRD achieved 85% of age-predicted heart rate, and no differences in exercise tolerance or LV function were observed. Valsalva's response was abnormal in patients with ESRD, and post exercise the norepinephrine level was markedly increased (12.5±1.43 vs 8.28 ±0.82 nmol/L). Our results fail to indicate an independent adverse effect of ESRD on LV function.(Arch Intern Med 1989;149:433-436)