RT Journal
T1 CArdioembolic stroke, early anticoagulation, and brain hemorrhage
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1987
FD April 1
VO 147
IS 4
SP 636
OP 640
DO 10.1001/archinte.1987.00370040018003
UL http://dx.doi.org/10.1001/archinte.1987.00370040018003
AB • Brain hemorrhage is a feared complication of early anticoagulation therapy in patients with cardioembolic brain infarction. We describe nine patients with cardioembolic stroke who experienced clinical deterioration associated with computed tomography—documented hemorrhagic transformation. The clinical features of these nine patients combined with 15 previously reported cases were analyzed to determine factors associated with hemorrhagic worsening. Patient age, embolic source, and intensity of anticoagulation were not associated with hemorrhagic worsening. Large infarct size and initiation of anticoagulation after early (<12 hours) computed tomography were associated with hemorrhagic transformation and clinical worsening in patients who received anticoagulation therapy.(Arch Intern Med 1987;147:636-640)