RT Journal
A1 Voigts AL, Felsenfeld AJ, Llach F
T1 The effects of calciferol and its metabolites on patients with chronic renal failure: I. calciferol, dihydrotachysterol, and calcifediol
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1983
FD May 1
VO 143
IS 5
SP 960
OP 963
DO 10.1001/archinte.1983.00350050120022
UL http://dx.doi.org/10.1001/archinte.1983.00350050120022
AB • The available data with regard to the use of calciferol, dihydrotachysterol, and calcifediol in the management of renal insufficiency are reviewed. Very limited data are available with regard to calciferol therapy; with the advent of more active metabolites, the use of calciferol is not warranted. Dihydrotachysterol seems to be effective in the treatment of renal patients with osteitis fibrosa; its low cost makes therapy with this compound a reasonable alternative, although it should not be used in the treatment of patients with liver disease. Calcifediol seems to be effective in patients with osteitis fibrosa; however, limited data on histologic characteristics of bone are available. Detailed prospective studies are necessary to establish the therapeutic benefit of calcifediol.(Arch Intern Med 1983;143:960-963)