RT Journal
A1 Walsh TJ, Mendelsohn G
T1 INvasive aspergillosis complicating cushing's syndrome
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1981
FD August 1
VO 141
IS 9
SP 1227
OP 1228
DO 10.1001/archinte.1981.00340090123028
UL http://dx.doi.org/10.1001/archinte.1981.00340090123028
AB • Patients with Cushing's syndrome are susceptible to opportunistic infections. Invasive fungal infections in patients with Cushing's syndrome caused by endogenous glucocorticoid excess rarely are reported, and aspergillosis occurring in this setting, to our knowledge, has not been described. Two patients with Cushing's syndrome and notably elevated levels of circulating cortisol had invasive aspergillosis develop. A patient with endogenous hypercortisolism caused by adrenal cortical carcinoma suffered a subarachnoid hemorrhage from rupture of an Aspergillus mycotic aneurysm. The other patient, who had an adrenocorticotrophic hormone-producing prostatic carcinoma, had pulmonary and disseminated aspergillosis develop. Exogenous corticosteroids are known clinically and experimentally to facilitate disseminated aspergillosis. Endogenous hypercortisolism also may be an important factor predisposing to invasive aspergillosis.(Arch Intern Med 1981;141:1227-1228)