RT Journal
A1 Heyden S, Heiss G
T1 COffee consumption-reply
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1979
FD October 1
VO 139
IS 10
SP 1195
OP 1195
DO 10.1001/archinte.1979.03630470102038
UL http://dx.doi.org/10.1001/archinte.1979.03630470102038
AB In Reply.— 
    This fascinating case report provides some evidence that excess use of coffee causes pathophysiologic changes leading to what Dr Stoffer correctly suspects, adrenal medullary hyperplasia. It is essential, however, to get some information on the quantity of caffeine consumed in order to determine dangerous levels of coffee intake. Unfortunately, this case report does not go into details on the kind of coffee preparation used nor the cup size. A great variety of caffeine concentrations with wide SDs have been published, ranging from 80 to 120 mg of caffeine in the "average" cup of brewed coffee, and from 66 to 100 mg of caffeine for instant coffee. Medical World News (1976) quoted as follows Dr Alan W. Burg's1 tests with 36 brands of coffee, tea, and sodas, using 180-mL cups: regular percolated coffee averaged 83 mg per cup and instant coffee, 59 mg. Gilbert et al2 presented