RT Journal
A1 Hubbard VS, Davis PB, di Sant'Agnese PA
T1 POssible hazard of timed-release aspirin in a patient with pancreatic insufficiency
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1979
FD September 1
VO 139
IS 9
SP 1054
OP 1055
DO 10.1001/archinte.1979.03630460084025
UL http://dx.doi.org/10.1001/archinte.1979.03630460084025
AB An episode of severe small intestinal hemorrhage occurred in a cystic fibrosis patient having pancreatic insufficiency and receiving timed-release aspirin therapy for disabling hypertrophic pulmonary osteoarthropathy. The increased acidity of small intestinal contents due to decreased bicarbonate secretion observed in patients with pancreatic insufficiency may alter the luminal environment and result in mucosal erosions and/or ulcerations in association with the presence of aspirin. Thus, physicians should be aware of the possibility that timed-release aspirin causes small intestinal hemorrhage in such patients.(Arch Intern Med 139:1054-1055, 1979)