RT Journal
A1 Holland O, Gomez-Sanchez CE, Kuhnert L, Poindexter C, Pak CC
T1 ANtihypertensive comparison of furosemide with hydrochlorothiazide for black patients
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1979
FD September 1
VO 139
IS 9
SP 1015
OP 1021
DO 10.1001/archinte.1979.03630460047016
UL http://dx.doi.org/10.1001/archinte.1979.03630460047016
AB Furosemide and hydrochlorothiazide were compared for treatment of black patients with mild to moderate hypertension in a randomized, open-label, crossover study design. Hydrochlorothiazide produced a significantly greater fall in mean arterial (24.7 vs 16.0 mm Hg, P <.01) and diastolic (17.3 vs 10.1 mm Hg, P <.01) blood pressure (BP) in 16 patients. Addition of methyldopa in nine patients produced a significantly greater fall in mean arterial (38.8 vs 31.9 mm Hg, P <.05) and diastolic (28.9 vs 23.4 mm Hg, P <.05) BP with hydrochlorothiazide vs furosemide. Renin status was categorized before and after treatment. Patients with low and normal renin activity were equally responsive to both diuretics. Hydrochlorothiazide caused a greater reduction in plasma potassium (0.26 mEq/L). Serum parathyroid hormone was not chronically elevated with furosemide. In this study, hydrochlorothiazide was more effective than furosemide for treatment of mild to moderate hypertension in black patients; renin classification did not predict diuretic responsiveness.(Arch Intern Med 139:1015-1021, 1979)