RT Journal
A1 Streck WF, Waterhouse C, Haddad JG
T1 GLucocorticoid effects in vitamin d intoxication
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1979
FD September 1
VO 139
IS 9
SP 974
OP 977
DO 10.1001/archinte.1979.03630460018009
UL http://dx.doi.org/10.1001/archinte.1979.03630460018009
AB Calcium balance studies and measurement of 25-hydroxyvitamin D (25[OH]D 3) levels were performed on a vitamin D intoxicated, hypoparathyroid patient before, during, and after successful management of hypercalcemia with oral prednisone therapy. Prednisone effected a dramatic reduction in both mean serum calcium levels and mean 24-hour urinary calcium excretion within four days on two separate occasions. No changes were apparent in fecal calcium excretion. Calcium balance became less negative with prednisone treatment. Levels of 25(OH) D during the same period did not change. Decreased calcium mobilization from bone best accounted for the glucocorticoid-mediated amelioration of hypercalcemia.(Arch Intern Med 139:974-977, 1979)