RT Journal
A1 Aisner J, Ross DD, Wiernik PH
T1 TAmoxifen in advanced male breast cancer
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1979
FD April 1
VO 139
IS 4
SP 480
OP 481
DO 10.1001/archinte.1979.03630410084025
UL http://dx.doi.org/10.1001/archinte.1979.03630410084025
AB A 47-year-old man with metastatic carcinoma of the breast was found to have positive estrogen and progesterone receptors but refused castration or estrogens. After failing on combination chemotherapy he was started on tamoxifen, which resulted in a partial response lasting seven months. He relapsed in bone and then consented to orchiectomy, which resulted in further clinical improvement. Thus, the tamoxifen did not preclude further hormonal therapy. This case, added to others reported, suggests that tamoxifen may be useful in the treatment of advanced male breast cancer. Further studies are needed to determine the level of activity, when to use the drug, and the predictive value of hormone receptors.(Arch Intern Med 139:480-481, 1979)