RT Journal A1 Petersdorf RG T1 HYpothermia JF Archives of Internal Medicine JO Archives of Internal Medicine YR 1979 FD April 1 VO 139 IS 4 SP 399 OP 399 DO 10.1001/archinte.1979.03630410009006 UL http://dx.doi.org/10.1001/archinte.1979.03630410009006 AB Man adapts to cold in a variety of ways: vasoconstriction reduces peripheral blood flow and maintains the temperature of the body core; shivering increases heat production; and modification of behavioral patterns results in better tolerance of abnormally low temperatures. Clinically, however, these adaptive mechanisms are rarely operative because hypothermia occurs by accident, usually in elderly, debilitated, or alcoholic individuals after prolonged exposures to low ambient temperatures. The usual history is that of a derelict found in a railroad yard or under a bridge following an alcoholic debauch, with a temperature of 28.5 to 32.3 °C or lower. Or a little old lady may be brought to the emergency room with hypothermia after suffering a stroke and lying helpless in an unheated apartment for a week or more. A variety of chronic diseases predispose to this syndrome, including myxedema—which is a much rarer cause of hypothermia than is usually thought—Addison's disease,