RT Journal
A1 Geiseler P, Check F, Lamothe F, Andersen BR
T1 FAilure of trimethoprim/ sulfamethoxazole in invasive nocardia asteroides infection
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1979
FD March 1
VO 139
IS 3
SP 355
OP 356
DO 10.1001/archinte.1979.03630400071025
UL http://dx.doi.org/10.1001/archinte.1979.03630400071025
AB A case of pulmonary nocardiosis occurred with progressive involvement of the pleura, pericardium, mediastinum, and sternum. Surgical resection and drainage procedures followed by administration of the drug combination, trimethoprim/sulfamethoxazole, over a six-month period led to clinical recovery. Discontinuation of drug therapy, however, was followed by relapse and further invasion by the same organism. A literature survey of Nocardia asteroides infections treated with trimethoprim/sulfamethoxazole disclosed that posttreatment follow-up is often too brief or unknown, making the ultimate success of therapy uncertain.(Arch Intern Med 139:355-356, 1979)