RT Journal
A1 Boyd NF, Clemens JD, Feinstein AR
T1 PRetherapeutic morbidity in the prognostic staging of acute leukemia
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1979
FD March 1
VO 139
IS 3
SP 324
OP 328
DO 10.1001/archinte.1979.03630400044018
UL http://dx.doi.org/10.1001/archinte.1979.03630400044018
AB To classify the clinical severity of acute leukemia, we have used the degrees of pretherapeutic infection and hemorrhage to construct a taxonomy containing three "stages." The stages are associated with survival gradients that are clinically and statistically distinctive in both acute lymphoblastic leukemia and acute nonlymphoblastic leukemia. Median survival ranged from 64.0 months for stage 1 to 10.5 months for stage 3 in acute lymphoblastic leukemia, and from 7.1 months for stage 1 to 1.2 months for stage 3 in acute nonlymphoblastic leukemia. The gradients, which persist when other prognostic factors and secular therapeutic changes are taken into account, are more distinctive than those found with other forms of stratification.(Arch Intern Med 139:324-328, 1979)