RT Journal
A1 Reynolds L, Bhathena D
T1 NEphrotic syndrome associated with methimazole therapy
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1979
FD February 1
VO 139
IS 2
SP 236
OP 237
DO 10.1001/archinte.1979.03630390088030
UL http://dx.doi.org/10.1001/archinte.1979.03630390088030
AB Thionamide drugs are widely used in the management of hyperthyroidism and are infrequently associated with adverse reactions. We report the development of the nephrotic syndrome during methimazole (Tapazole) therapy in a young man with Graves' disease. His proteinuria remitted promptly with discontinuance of the drug, and renal histologic features bore a striking resemblance to the toxic nephrosis induced in animals by the aminonucleoside of puromycin. In view of the histologic similarities, we propose that methimazole acted as a direct glomerular toxin, inducing the nephrotic syndrome in this patient.(Arch Intern Med 139:236-237, 1979)