RT Journal
A1 Samaan NA, Stepanas AV, Danziger J, Trujillo J
T1 REactive pituitary abnormalities in patients with klinefelter's and turner's syndromes
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1979
FD February 1
VO 139
IS 2
SP 198
OP 201
DO 10.1001/archinte.1979.03630390050021
UL http://dx.doi.org/10.1001/archinte.1979.03630390050021
AB Ten unselected patients with gonadal dysgenesis, three with Klinefelter's and seven with Turner's syndromes, were studied. Two of the patients with Klinefelter's and two with Turner's syndromes had enlarged pituitary fossae. The other six patients had normal sized sella, but showed localized change in the sellar contour on polytomography, suggesting hyperplasia or microadenoma formation of the pituitary gland.All ten patients had abnormally high serum follicle-stimulating hormone levels both at basal and after luteinizing hormone-releasing hormone stimulation.These results suggest that hyperplasia or microadenoma of the pituitary gland may occur secondary to gonadal failure, producing enlarged volume or attenuation in the normal contour of the sella turcica. Lack of awareness of reactive pituitary changes secondary to gonadal failure may result in inappropriate surgical management of what may appear to be primary pituitary tumor.(Arch Intern Med 139:198-201, 1979)