RT Journal
A1 Pont A, Rubino JM, Bishop D, Peal R
T1 DIabetes mellitus and neuropathy following vacor ingestion in man
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1979
FD February 1
VO 139
IS 2
SP 185
OP 187
DO 10.1001/archinte.1979.03630390039016
UL http://dx.doi.org/10.1001/archinte.1979.03630390039016
AB Two patients ingested Vacor, a rodenticide containing the active ingredient N-3 pyridylmethyl-N′-p-nitrophenyl urea. Both patients developed ketosis-prone diabetes mellitus and severe autonomic neuropathy. Niacinamide therapy given nine hours after Vacor ingestion in one patient and 14 hours after ingestion in the other was not successful in preventing these sequelae. Physicians need to be aware of the toxicity of Vacor, and the potential therapeutic benefit of early niacinamide therapy.(Arch Intern Med 139:185-187, 1979)