RT Journal
A1 Russell RG, Bisaz S, Fleisch H
T1 PYrophosphate and diphosphonates in calcium metabolism and their possible role in renal failure
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1969
FD November 1
VO 124
IS 5
SP 571
OP 577
DO 10.1001/archinte.1969.00300210053007
UL http://dx.doi.org/10.1001/archinte.1969.00300210053007
AB We have recently suggested that inorganic pyrophosphate may be a physiological inhibitor of calcification in soft tissues and a physiological regulator of calcium homeostasis through its effect on the formation and destruction of mineralized tissues.1-6 This communication is concerned with the possible role of pyrophosphate in the metastatic calcification and bone disease associated with renal failure.Mineralization in General 
    Very little is known of the mechanisms responsible for the deposition of calcium salts at normal or abnormal sites within the body. In recent years some clarification has come from studies on the mechanism of precipitation in vitro. It is now established that the concentrations of calcium and phosphate in plasma, extracellular fluid, and even in fluid withdrawn from calcifying cartilage 7 are much lower than those required to form crystals in vitro.1,8 The formation of apatite crystals in vivo therefore requires some local promoting mechanism at the site