RT Journal
A1 Loeb HS, Pietras RJ, Ninos N, Tobin JR, Jr., Gunnar RM
T1 HEmodynamic responses to chlorpromazine in patients in shock
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1969
FD September 1
VO 124
IS 3
SP 354
OP 358
DO 10.1001/archinte.1969.00300190094015
UL http://dx.doi.org/10.1001/archinte.1969.00300190094015
AB Hemodynamic measurements were obtained from 18 patients in shock before and after administration of chlorpromazine. Mean arterial pressure fell in all but one patient due to a reduction in systemic vascular resistance. Improved cardiac output occurred in nine patients, who, when compared to the others, had higher arterial and central venous pressures, higher vascular resistances, and had shown a poorer response to plasma volume expansion. These observations suggest that chlorpromazine will reduce vascular resistance in most patients in shock, but will not improve cardiac output if central aortic pressure is low or previous fluid replacement has been inadequate.