RT Journal
A1 Spaet TH, Lejnieks I, Gaynor E, Goldstein ML
T1 DEfective platelets in essential thrombocythemia
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1969
FD August 1
VO 124
IS 2
SP 135
OP 141
DO 10.1001/archinte.1969.00300180007002
UL http://dx.doi.org/10.1001/archinte.1969.00300180007002
AB Platelets from three consecutive patients with essential thrombocythemia were studied. In each case there were characteristic abnormalities. These included absent aggregation in response to epinephrine and reduced aggregation by adenosine diphosphate. The platelets were aggregated normally by collagen. Uptake by platelets of serotonin labeled with radioactive carbon 14C was reduced, and there was possibly reduced platelet adenosine diphosphatase activity. The platelets supported normal clot retraction, and gave normal platelet factor 3 availability. The abnormality appears to be specific for the disease rather than a nonspecific reflection of thrombocythemia.