RT Journal
A1 Sandstead HH, Stant EG, Brill A, Arias LI, Terry RT
T1 LEad intoxication and the thyroid
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1969
FD June 1
VO 123
IS 6
SP 632
OP 635
DO 10.1001/archinte.1969.00300160022004
UL http://dx.doi.org/10.1001/archinte.1969.00300160022004
AB Thyroid function has been studied in 24 patients judged to have saturnism on the basis of their urinary excretion of lead following an infusion of edetate calcium disodium. Following administration of sodium iodide I 131 the mean 24 hour 131I uptake for 23 was 10.0% ± 3.7% SD. A single patient had an uptake of 26.1%. All but three patients responded normally to stimulation with thyroid stimulating hormone. Of two patients studied, one had a decreased secretion of thyroxine by the thyroid. Other measures of thyroid function were normal in the group. The findings are consistent with injury of the iodine concentrating mechanism of the thyroid.