RT Journal
A1 Felig P, Marliss E, Owen OE, Cahill GF, Jr.
T1 BLood glucose and gluconeogenesis in fasting man
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1969
FD March 1
VO 123
IS 3
SP 293
OP 298
DO 10.1001/archinte.1969.00300130075011
UL http://dx.doi.org/10.1001/archinte.1969.00300130075011
AB Maintenance of blood glucose homeostasis in fasting man requires establishment of a fine balance between glucose production and utilization. Early in starvation, a decrease in serum insulin provides the alterations in substrate concentration and enzymatic activity conducive to augmented gluconeogenesis. As fasting progresses, glucose utilization is reduced as the brain consumes ketone bodies. A concomitant reduction in total gluconeogenesis is brought about by a reduction in plasma amino acid levels, particularly alanine.