RT Journal
A1 Madison LL
T1 ROle of insulin in the hepatic handling of glucose
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1969
FD March 1
VO 123
IS 3
SP 284
OP 292
DO 10.1001/archinte.1969.00300130066010
UL http://dx.doi.org/10.1001/archinte.1969.00300130066010
AB The effects of insulin on hepatic glucose balance, including data on hepatic glucose output, production (glycogenolysis and gluconeogenesis), and uptake in normal and diabetic animals are reviewed. Data from in vivo studies are presented which indicate that these changes in the hepatic handling of glucose following insulin administration are direct effects of insulin on the liver rather than effects secondary to insulin's action on muscle and adipose tissue. These studies indicate that these hepatic actions of insulin are vital to the organism both during feasting and prolonged fasting.