RT Journal
A1 Bressler R, Cordon M, Brendel K
T1 STudies on the role of adenylcyclase in insulin secretion
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1969
FD March 1
VO 123
IS 3
SP 248
OP 251
DO 10.1001/archinte.1969.00300130030005
UL http://dx.doi.org/10.1001/archinte.1969.00300130030005
AB The administration of glucose, tolbutamide, corticotropin, and glucagon to mice resulted in stimulation of insulin secretion. These stimulations were all inhibited by the prior administration of β-adrenergic receptor blocking agents. Cyclic 3',5' adenosine monophosphate stimulated insulin secretion in intact mice and its stimulatory effect was also inhibited by β-adrenergic receptor blocking agents. The locus of the inhibitory effects of β-adrenergic receptor blocking agents on insulin secretion is discussed.