RT Journal
A1 Lee SL, Rosner F, Crosby WH
T1 TReatment of agl
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1969
FD February 1
VO 123
IS 2
SP 205
OP 207
DO 10.1001/archinte.1969.00300120093017
UL http://dx.doi.org/10.1001/archinte.1969.00300120093017
AB To the Editor. 
    —The editorial by William H. Crosby, MD, "To Treat or Not to Treat Acute Granulocytic Leukemia" (Arch Intern Med122: 79-80 [July] 1968), prompts the following comments.The decision whether or not to treat intensively a given patient with acute granulocytic leukemia (AGL) is indeed a difficult one. In his editorial, Dr. Crosby attempts to resolve the problem by listing a series of six variants of AGL in which "the remission rate is zero," and in which, therefore, treatment other than general support is not indicated.Our experience does not accord with Dr. Crosby's dicta. Over the past six years we have personally observed 169 patients with AGL who have been treated within two weeks (usually within a few days) of the time of diagnosis. These patients have all been treated on studies of the Acute Leukemia Cooperative Chemotherapy Group B (ALB) with one or several of