RT Journal
A1 Foley H, Bennett JM
T1 COmbination chemotherapy of chronic
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1969
FD February 1
VO 123
IS 2
SP 166
OP 170
DO 10.1001/archinte.1969.00300120054010
UL http://dx.doi.org/10.1001/archinte.1969.00300120054010
AB Thirteen patients with chronic granulocytic leukemia who had entered an accelerating phase ("blast crisis") of their illness were treated with a combination of agents known to be effective in both acute granulocytic and acute lymphocytic leukemia, (prednisone, mercaptopurine, and methotrexate; vincristine sulfate was added in five instances). Only one complete clinical remission was seen. One marrow remission in the face of increasing adenopathy was seen; there were two partial remissions. The toxicity was severe and included four drug-related deaths.