RT Journal
A1 Rand JJ, Moloney WC, Sise HS
T1 COagulation defects in acute promyelocytic leukemia
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1969
FD January 1
VO 123
IS 1
SP 39
OP 47
DO 10.1001/archinte.1969.00300110041007
UL http://dx.doi.org/10.1001/archinte.1969.00300110041007
AB Four patients with acute promyelocytic leukemia manifested multiple coagulation abnormalities including hypofibrinogenemia, prolongation of prothrombin and thrombin times, and varying deficiencies of coagulation factors. One of the patients (patient 2) showed rising levels of fibrinogen without changes in other coagulation factors on heparin therapy and demonstrated widespread intravascular coagulation on postmortem examination. Another patient (patient 1) had positive tests for active fibrinolysis and an absolute lack of the usual postmortem thrombi. The current hypotheses of the pathogenesis of the coagulation abnormalities are presented as well as guide to therapeutic management.