RT Journal
A1 SHINABERGER JH
T1 TReatment of methanol poisoning by extracorporeal dialysis
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1961
FD December 1
VO 108
IS 6
SP 937
OP 939
DO 10.1001/archinte.1961.03620120121016
UL http://dx.doi.org/10.1001/archinte.1961.03620120121016
AB The studies of Marc-Aurele and Schreiner have shown that methanol is a readily dialyzable substance, that early dialysis in methanol-poisoned dogs is successful in preventing blindness, and that the presence of ethanol does not interfere with the dialysance of methanol.1 That the presence of ethanol inhibits the metabolism of methanol to its more toxic oxidative products has been adequately demonstrated.2-5 This information has outlined a method for the ideal early treatment of methanol poisoning by blockade of its metabolism with simultaneous ethanol infusion and rapid removal of methanol, prior to its oxidation, by dialysis.Stinebaugh has recently reported 3 cases of severe methyl alcohol poisoning treated with peritoneal dialysis with recovery but loss of sight in 2 patients.6 The third patient died. Although Stinebaugh demonstrated effective removal of methanol by this method, dialysis required 20-24 hours. It is felt that the rather prolonged period of time required