RT Journal
A1 BLOODWORTH JB, JR.
T1 DIabetes mellitus and cirrhosis of the liver
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1961
FD November 1
VO 108
IS 5
SP 695
OP 701
DO 10.1001/archinte.1961.03620110035006
UL http://dx.doi.org/10.1001/archinte.1961.03620110035006
AB One of the first pathologic changes described in the diabetic patient was an enlarged, fatty liver.1 Since that time, numerous studies have indicated that a fatty liver is present in from 15% to 50% of diabetic patients.2,3 Laboratory evidence of liver dysfunction is present in a significant percentage of diabetic patients.3-5Fatty metamorphosis of the liver is an integral part of the pathologic picture in the majority of cases of cirrhosis of the liver.6 Many investigators have stated that if a fatty liver from any cause persists, cirrhosis will develop.7 Chaikoff and Connor reported that the production of a fatty liver in the dog by a high-fat diet will ultimately lead to cirrhosis of the liver.8 Pancreatectomized dogs maintained on insulin develop a fatty liver and ultimately show cirrhosis of the liver.9Despite these facts, a direct relationship between diabetes mellitus and cirrhosis