RT Journal
A1 YOW EM, TAN E, SHANE L, SCHONFELD S, ABU-NASSAR H
T1 Colistin(coly-mycin) in resistant bacterial infections: A clinical appraisal
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1961
FD November 1
VO 108
IS 5
SP 664
OP 670
DO 10.1001/archinte.1961.03620110004002
UL http://dx.doi.org/10.1001/archinte.1961.03620110004002
AB Among the new antibiotics investigated clinically in Houston during the past two years, colistin (Coly-Mycin) has been one of the most promising. This antibiotic was isolated in Japan by Yosuo Koyama in 1950 from culture filtrates of Bacillus colistinus, a bacterium closely related to Bacillus polymyxa, the source of the polymyxins. Its pharmacology has been studied in Japan, Italy, France, and, more recently, this country. A summary of the findings of these studies indicates that the chemical, pharmacological, and antimicrobial activity of colistin is closely related to the polymyxins, Clinically, however, colistin causes fewer undesirable side-effects.Colistin is a complex polypeptide, with an empirical formula of C45H85O10N13 and a molecular weight of 969. Its acid salts are stable in solution even for very long periods; alkaline salts are less stable. It is available as colistin sulfate for oral and ophthalmic use, and as