RT Journal
A1 REINFRANK RF
T1 PRimary hyperparathyroidism with depression
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1961
FD October 1
VO 108
IS 4
SP 606
OP 610
DO 10.1001/archinte.1961.03620100098014
UL http://dx.doi.org/10.1001/archinte.1961.03620100098014
AB Prior to 1925, the occasional autopsy findings of enlargement of the parathyroid glands in patients with generalized bone disease were thought to be the result of a compensatory hypertrophy of the glands. In 1925 Felix Mandl treated a patient with generalized osteitis fibrosa with injections of parathyroid extract and attempts at parathyroid transplants. Since the patient did not improve, a neck exploration was done, and an adenomatous enlargement of one of the parathyroids was found and removed. The patient steadily improved.1The demonstration that a serious metabolic disorder of bone could be surgically corrected stimulated a widespread interest in the early diagnosis of primary hyperparathyroidism which has continued to the present. Metabolic bone disease of the osteitis fibrosa variety, nephrolithiasis or nephrocalcinosis, or a combination of these manifestations, have been the clinical hallmarks of primary hyperparathyroidism.In 1957 St. Goar called attention to the frequency with which gastrointestinal symptoms