RT Journal
A1 DeGOWIN EL, HODGES RE, HAMILTON HE, EVANS TC
T1 THyrotoxicosis treated with small repeated doses of radioiodine
JF A.M.A. Archives of Internal Medicine
JO A.M.A. Archives of Internal Medicine
YR 1959
FD December 1
VO 104
IS 6
SP 959
OP 965
DO 10.1001/archinte.1959.00270120115015
UL http://dx.doi.org/10.1001/archinte.1959.00270120115015
AB An ultimate objective in the treatment of hyperthyroidism with radioactive I131 has been to develop a method of selecting for each patient a dose of the isotope which will destroy precisely enough thyroid tissue to produce the euthyroid state. The application of such a method would eradicate the therapeutic sequelae of radiation thyroiditis, thyroid storm, and myxedema. Protraction of the hyperthyroid state would not occur in patients who now require supplementary doses to correct for the inadequacy of the initial attempt.Although a search for a satisfactory method of dose prediction has been in progress since radioiodine was first used, in 1941, in the Massachusetts General Hospital,5 no ideal solution has yet been found. The thyroidal uptake of I131 can be measured by tracer doses of the isotope, but the mass of the thyroid gland can only be estimated with great error, either by palpation or by