RT Journal A1 MANN GV T1 DIet and coronary heart disease JF A.M.A. Archives of Internal Medicine JO A.M.A. Archives of Internal Medicine YR 1959 FD December 1 VO 104 IS 6 SP 921 OP 929 DO 10.1001/archinte.1959.00270120077012 UL http://dx.doi.org/10.1001/archinte.1959.00270120077012 AB The most pressing medical problem of the Western World is that of coronary heart disease. The past 15 years have seen a revolution in attitude toward this problem. The old pessimistic view that atherosclerosis is inevitable and immutable has given way to an optimism that atherosclerosis can be reduced to its chemical parts, can be known, and, in time, prevented. These new opinions are suspended upon a tenuous network of hypotheses that sway and tear in the face of criticism, prejudice, and windy debate. Nevertheless, the hypotheses are useful and indispensable parts of the scientific method, and they deserve careful tending. Chief among them is a belief that diet is important to the pathogenesis of atherosclerotic disease.It would be vain to suppose that man is so ingenious that he would never devise some piece of progress which would backbite him. It is worth considering that a way of life