RT Journal
A1 ROBINSON RW, HIGANO N, COHEN WD
T1 INcreased incidence of coronary heart disease in women castrated prior to the menopause
JF A.M.A. Archives of Internal Medicine
JO A.M.A. Archives of Internal Medicine
YR 1959
FD December 1
VO 104
IS 6
SP 908
OP 913
DO 10.1001/archinte.1959.00270120064010
UL http://dx.doi.org/10.1001/archinte.1959.00270120064010
AB There is increasing evidence to suggest that multiple factors, including heredity, occupation, diet, stress, and preexisting hypertension, diabetes mellitus, hypercholesterolemia, and obesity, are involved in the pathogenesis of coronary heart disease. It has also been observed for many years that women have less coronary disease than men. As long ago as 1803, William Heberden recorded that there were only 3 women in nearly 100 patients with pectoris dolor (angina pectoris).1 In a series of 30,000 autopsies, Clawson found a malefemale ratio of 8:1 among patients with coronary sclerosis without hypertension.2 Clinical studies of coronary heart disease have also shown a sex difference, Levy and Boas3 reporting a male-female ratio of 4.9:1, and Master, Dack, and Jaffe4 reporting 3.4:1. These studies have confirmed the observation that women have a decreased incidence of coronary atherosclerosis as compared with men.Even more striking is the rarity of this disease in women under 40