RT Journal
A1 SUHRLAND LG, RUBIN D, WEISBERGER AS, MEACHAM GC
T1 FAilure of oral therapy in the maintenance of pernicious anemia
JF A.M.A. Archives of Internal Medicine
JO A.M.A. Archives of Internal Medicine
YR 1959
FD September 1
VO 104
IS 3
SP 411
OP 416
DO 10.1001/archinte.1959.00270090065011
UL http://dx.doi.org/10.1001/archinte.1959.00270090065011
AB Introduction 
    Oral administration of cyanocobalamin (vitamin B12) and intrinsic factor derived from hog stomach is known to be effective in producing remissions in patients with pernicious anemia in relapse. However, the efficacy of maintenance therapy with such preparations has been more difficult to evaluate. Short-term studies have indicated that satisfactory remission can be maintained on an oral preparation containing both cyanocobalamin and intrinsic factor.1 Likewise, massive oral doses of cyanocobalamin without intrinsic factor may maintain patients with pernicious anemia in remission.2-4 Since it has been observed that it may take several months to years for some patients with pernicious anemia to relapse, evaluation of a treatment program should be based upon a long-term study. The purpose of the present report is to compare the effectiveness of an oral preparation with that of parenteral cyanocobalamin in the management of pernicious anemia over a three-year period.During the observation