RT Journal
A1 SUGAR SN, THOMAS LJ, EUGENIO TM
T1 CHlorpropamide in the management of diabetes
JF A.M.A. Archives of Internal Medicine
JO A.M.A. Archives of Internal Medicine
YR 1959
FD September 1
VO 104
IS 3
SP 360
OP 364
DO 10.1001/archinte.1959.00270090014003
UL http://dx.doi.org/10.1001/archinte.1959.00270090014003
AB Chlorpropamide is a new oral antidiabetic agent. Its chemical name is N-propyl-N'-(p-chloro-benzenesulfonyl)urea. The structural formula (Fig. 1) is similar to other sulfonamide derivatives which have been observed to have a blood-sugar-lowering effect.Schneider et al.,1 in a thorough pharmacological study of more than two years' duration, found chlorpropamide to be an effective, orally active hypoglycemic agent. In the rhesus monkey, this compound was found to be considerably more potent than tolbutamide and, in addition, the duration of the hypoglycemic effect was more prolonged.The purpose of the investigation reported here was to confirm the antidiabetic properties of chlorpropamide in the human, to study its therapeutic effectiveness, and to disclose the presence or absence of significant side-effects. In particular we wished to observe the effectiveness of chlorpropamide in those patients who were unresponsive to tolbutamide.Method of Study 
    Diabetic patients who were taking insulin, those inadequately controlled with tolbutamide, and an