RT Journal
A1 SCHWARTZ RD, BRODOFF M, COHN GL, SPIRO HM
T1 REctal cortisol in the therapy of ulcerative colitis
JF A.M.A. Archives of Internal Medicine
JO A.M.A. Archives of Internal Medicine
YR 1959
FD August 1
VO 104
IS 2
SP 260
OP 263
DO 10.1001/archinte.1959.00270080086011
UL http://dx.doi.org/10.1001/archinte.1959.00270080086011
AB The successful use of topical steroid therapy in diseases of the eye, skin, and joints has led to an evaluation of the effect of cortisol enemas in idiopathic ulcerative colitis. Observations from this laboratory have implied negligible absorption of cortisone from the rectum in ulcerative colitis. and so a relative absence of side-effects was to be anticipated.1 Truelove and others have reported encouraging results with rectal hydrocortisone in ulcerative colitis.2,3 This report represents an attempt to define the type of patient in whom such therapy might be most helpful.Methods 
    All 16 patients studied had the diagnosis of ulcerative colitis confirmed by sigmoidoscopy and x-ray examination at either the Grace-New Haven Community Hospital or the West Haven Veterans Administration Hospital. Stool examinations were performed to exclude amebiasis, bacillary dysentery, and other causes of diarrhea; many patients had received antiamebic therapy on an empirical basis. Table 1 illustrates an