RT Journal
A1 BRUYN HB, LENNETTE EH
T1 IMmunological evaluation of monovalent influenza vaccine in adults and in children
JF A.M.A. Archives of Internal Medicine
JO A.M.A. Archives of Internal Medicine
YR 1959
FD June 1
VO 103
IS 6
SP 914
OP 923
DO 10.1001/archinte.1959.00270060066009
UL http://dx.doi.org/10.1001/archinte.1959.00270060066009
AB The characteristic ability of influenza viruses to undergo variation in antigenic structure has given rise to a new family of influenza A strains, now officially referred to as the "Asian family." 1 With the first recognized appearance and isolation of this new virus, early in 1957, and the decision to develop vaccines for active immunization against this new antigenic variant,2 emphasis was placed anew on problems which required a review of our previous knowledge of the antigenic behavior of Type A influenza viruses as well as of the immunologic response in man when exposed to new variants of the Type A group of viruses.Early studies on antigenic variants of influenza A viruses showed that protection induced by active immunization was greatest against the homologous virus strain and that the efficacy of immunization against heterologous strains depended upon antigenic relationships between the immunizing and the infecting virus strains.3