RT Journal
A1 QUICK AJ, HUSSEY CV
T1 HEmophilia b (ptc deficiency, or christmas disease)
JF A.M.A. Archives of Internal Medicine
JO A.M.A. Archives of Internal Medicine
YR 1959
FD May 1
VO 103
IS 5
SP 762
OP 775
DO 10.1001/archinte.1959.00270050084014
UL http://dx.doi.org/10.1001/archinte.1959.00270050084014
AB In 1947, it was shown by means of a new procedure, the prothrombin consumption test, that blood did not contain thromboplastin either free or in a precursor state but that it was formed as the result of an interaction between a platelet factor and what was assumed to be at that time a single plasma constituent which was lacking in hemophilia.1 Five years later Schulman and Smith2 reported a patient whose clinical condition was indistinguishable from hemophilia but whose defective prothrombin-consumption time was corrected by plasma from a known hemophiliac. They concluded that their patient lacked a plasma factor different from thromboplastinogen, the agent deficient in hemophilia, but which was equally as essential for the formation of plasma thromboplastin. No specific name other than X was given to this new factor. Interestingly, a week after Schulman and Smith sent their manuscript for publication, Aggeler and his associates 3