RT Journal
A1 CASTLE C, CONRAD JK, HECHT HH
T1 OBservations on the diuretic effect of chlorothiazide
JF A.M.A. Archives of Internal Medicine
JO A.M.A. Archives of Internal Medicine
YR 1959
FD March 1
VO 103
IS 3
SP 415
OP 420
DO 10.1001/archinte.1959.00270030071007
UL http://dx.doi.org/10.1001/archinte.1959.00270030071007
AB Chlorothiazide* (6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide) has been shown to be a potent diuretic substance when given either orally or parenterally.1-4 Its major effect as a diuretic consists of increasing renal excretion of sodium and chloride, presumably by a decrease in tubular reabsorption, with a secondary loss of water. In vitro chlorothiazide has mild carbonic-anhydrase-inhibition action (approximately 10 times that of sulfanilamide and 1/25 that of acetazolamide [Diamox] ); however, this effect has not been implicated as playing a significant role in diuresis in vivo.1,3 This drug was used in the present study to evaluate its possible mode of action and its effectiveness as a diuretic.Methods and Materials 
    This study was divided into two parts: (1) changes in cardiac and renal hemodynamics and in water and electrolyte excretion following intravenous chlorothiazide, and (2) effectiveness of oral chlorothiazide in patients with edema, as evidenced by diuresis and by the changes in electrolyte excretion.