RT Journal
A1 PETERSEN A, DODGE M, HELWIG FC
T1 PUlmonary changes associated with hexamethonium therapy
JF A.M.A. Archives of Internal Medicine
JO A.M.A. Archives of Internal Medicine
YR 1959
FD February 1
VO 103
IS 2
SP 285
OP 288
DO 10.1001/archinte.1959.00270020113013
UL http://dx.doi.org/10.1001/archinte.1959.00270020113013
AB Since 1953 several reports of pulmonary lesions developing concurrently with hexamethonium therapy for hypertension have been recorded. The lesions have been described as similar but not always identical to acute diffuse interstitial pulmonary fibrosis as described by Hamman and Rich.1In 1953, Morrison 2 reported 39 cases of hypertension treated with parenteral hexamethonium, with the development of dyspnea and bilateral symmetrical opacities on chest roentgenograms in three patients treated for 7, 9, and 15 months, respectively. One of these patients died, and autopsy revealed extensive central carnification of both lungs. A subsequent report by Doniach, Morrison, and Steiner,3 apparently on the same three patients, showed both an intra-alveolar and an interstitial pulmonary fibrosis in the two patients who died. One atient recovered, with improvement as observed in the chest x-ray.Morrow, Schroeder, and Perry4 mention five cases of hypertension treated with hexamethonium and hydralazine in which interstitial