RT Journal
A1 SILVERTHORNE M
T1 STaphylococcal bacteremia and osteomyelitis successfully treated with novobiocin
JF A.M.A. Archives of Internal Medicine
JO A.M.A. Archives of Internal Medicine
YR 1959
FD January 1
VO 103
IS 1
SP 133
OP 139
DO 10.1001/archinte.1959.00270010139018
UL http://dx.doi.org/10.1001/archinte.1959.00270010139018
AB Novobiocin (Cathomycin), derived from the actinomycete Streptomyces spheroides, has now been added to the growing list of antibiotics useful in clinical medicine. Recent studies 1-8 have shown this drug to be effective in infections due to many Gram-positive and a few Gram-negative organisms, and there has been particular interest in the demonstration that novobiocin is active against many strains of Staphylococcus.The following case report illustrates the effectiveness of novobiocin used in the treatment of a patient with staphylococcal bacteremia and focal areas of osteomyelitis. In addition, the case is of interest because, while under treatment, the patient developed a reaction to the novobiocin, which subsided spontaneously despite the continued use of the drug.Report of Case 
    The patient, a 58-year-old white man, was admitted to the Medical Service of the McKinney Veterans' Administration Hospital for the fourth time on Dec. 31, 1955, complaining chiefly of intermittent feverishness, chilly sensations,