RT Journal
T1 Insulin: Its chemistry and physiology.
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1939
FD November 1
VO 64
IS 5
SP 1129
OP 1130
DO 10.1001/archinte.1939.00190050235015
UL http://dx.doi.org/10.1001/archinte.1939.00190050235015
AB This monograph is a timely and important addition to the literature on insulin and carbohydrate metabolism. The purpose of the author, as stated in the preface, was "to give a comprehensive review of the latest developments in the chemical and physiological investigations of insulin." This purpose has been admirably achieved. In the first chapter the history of the investigations which culminated in the recognition of the relation between the islands of Langerhans and human and experimental diabetes is surveyed, along with mention of some of the early attempts to prepare active extracts of the pancreas (some of these extracts undoubtedly contained insulin), which were made prior to the successful solution of this problem by Banting and Best in 1921. After this are chapters on the preparation and purification of insulin, the chemistry of insulin as elucidated by the study of crystal line insulin, the standardization of insulin, modes of administration