RT Journal
A1 ALLAN W
T1 RElation of hereditary pattern to clinical severity as illustrated by peroneal atrophy
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1939
FD June 1
VO 63
IS 6
SP 1123
OP 1131
DO 10.1001/archinte.1939.00180230108008
UL http://dx.doi.org/10.1001/archinte.1939.00180230108008
AB Field work in the inheritance of human disease has brought to light two striking phenomena:First, in regard to many of the diseases due to unit traits, that is, conditioned by a single defective gene, a wide survey of 50 to 100 families possessing such a trait usually shows a triple pattern of inheritance: dominant, sex-linked recessive and simple recessive.How general this rule is in human, animal or plant genetics is not known, nor is it obvious why the same trait should be dominant in 1 family and recessive in a second and in a third ride the sex chromosomes down the generations, becoming manifest only in the males.The second phenomenon, a corollary of the first, is that the pattern of inheritance determines the age of onset and the clinical severity of various morbid unitary traits, as may be seen by a study of peroneal atrophy (Charcot-Marie-Tooth type).