RT Journal
A1 MOEHLIG RC, BATES GS
T1 INfluence of the pituitary gland on erythrocyte formation
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1933
FD February 1
VO 51
IS 2
SP 207
OP 235
DO 10.1001/archinte.1933.00150210037004
UL http://dx.doi.org/10.1001/archinte.1933.00150210037004
AB In this article we shall endeavor to show that: (a) The pituitary secretion has a very important influence on erythrocyte formation. (b) Primary disease of the suprarenal cortex results in secondary pituitary changes, thus accounting for many signs and symptoms erroneously ascribed to the suprarenal cortex. (c) The specific and selective embryohormonic relations of the pituitary gland to mesodermal tissues is a reasonable explanation for the polymorphic signs and symptoms of pituitary disturbances.Two cases of polycythemia vera with pituitary basophilism, coming to autopsy, and polycythemias experimentally induced in dogs by bilateral adrenalectomy form the basis of our report.Our interest in the erythropoietic function of the pituitary was the result of some clinical observations which pointed to this gland as the major factor in stimulating the hematopoietic system to erythrocyte formation.While we were engaged in carrying out the experimental part of the work, a splendid article by