RT Journal
A1 COOK JE, SOMOGYI M
T1 THe rate of glycolysis in erythremia (polycythemia vera)
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1929
FD December 1
VO 44
IS 6
SP 813
OP 817
DO 10.1001/archinte.1929.00140060028003
UL http://dx.doi.org/10.1001/archinte.1929.00140060028003
AB In a recent article by Falcon-Lesses,1 the author applied the observations of Warburg and Murphy and Hawkins on glycolysis in malignant disease to the apparently similar problem of glycolysis in leukemic blood. He found that, whereas in normal persons glycolysis in blood containing not more than 100 mg. of dextrose per hundred cubic centimeters is completed in about six hours, in the blood of patients with myelogenous leukemia the process was from two to three times as rapid, being complete in from one to four hours.In seeking some explanation of the mechanism of this process, Falcon-Lesses made observations in two other cases showing abnormal conditions of the blood, one of polycythemia with a red cell count of 9,505,000 and a white cell count of 25,775 and the other a case of pernicious anemia with a red cell count of 2,800,000 and a white cell count of 4,000. The rate