RT Journal
A1 NEWBURGH LH
T1 THe production of bright's disease by feeding high protein diets
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1919
FD October 1
VO 24
IS 4
SP 359
OP 377
DO 10.1001/archinte.1919.00090270003001
UL http://dx.doi.org/10.1001/archinte.1919.00090270003001
AB For nearly a century the etiology of Bright's disease has been the subject of much medical thought and investigation. But in spite of this, the clinician is still unable to find a cause for the disease in the great majority of cases seen by him. The present investigation was undertaken with the hope of throwing some additional light on this difficult subject.The chief business of the kidneys is to rid the organism of the end products of protein metabolism. This task is accomplished to a considerable extent by active secretion on the part of certain portions of the tubular epithelium. These cells will not only remove normal waste, but they will also remove from the blood stream substances which are foreign to it even though they may be severely injured by the poisons passing through them. Thus investigators1 have shown that when the kidney eliminates such substances as mercury,