RT Journal
A1 WAGO HH
T1 OBservations concerning the pathology of pancreatic ferments
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1919
FD February 1
VO 23
IS 2
SP 251
OP 268
DO 10.1001/archinte.1919.00090190121010
UL http://dx.doi.org/10.1001/archinte.1919.00090190121010
AB INTRODUCTION 
    At present it is generally recognized that almost all enzymes seem to be toxic when introduced into animal bodies. The first thorough study of the toxicity of enzymes was made by Hildebrandt1 in 1890. He found that pepsin, diastase, chymosin, emulsin, invertase and myrosin were all toxic; so much so that they produced trembling, uneasiness, difficulty in walking, dyspnea and rising temperature as symptoms. In addition there were numerous hemorrhages from serous and mucous membranes, the lungs, muscles, kidneys, intestines and brain; thrombosis in the body; interference with blood coagulation; fatty degeneration of the myocardium; fatty and parenchymatous degeneration of the liver and hyperemia and parenchymatous and fatty degeneration of the kidney as anatomic changes.In 1899 Piquet2 also observed that trypsin and pepsin increased the coagulability of the blood, but after such increase thrombosis frequently occurred.Morgenroth3 found that injection of lab ferment subcutaneously caused an abscess at