RT Journal
A1 Emmanuel A, Maloisel F
T1 Drug-associated agranulocytosis: Experience at strasbourg teaching hospital
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1999
FD October 1
VO 159
IS 19
SP 2366
OP 2367
DO 
UL http://dx.doi.org/
AB 
Fifty-eight episodes of drug-induced agranulocytosis (neutrophil count, <0.5×109/L; all patients fulfilled the criteria of Benichou and Solal-Celignoy3) were treated at Strasbourg Teaching Hospital, Strasbourg, France, between January 1985 and January 1997. The mean age of the patients was 65.7 years, and the female-male ratio was 1:4. During hospitalization, all patients had at least 1 of the following manifestations: isolated fever and chills (17/58 [31%]), sore throat (13/58 [22.4% ]), septicemia (12/58 [21%]), pneumonia (11/58 [14%]), or other localized infections (7/58 [11.6%]). The mean neutrophil count was 0.09×109/L, and 36 patients (62%) had a neutrophil count less than 0.1×109/L. The incidence of drug-associated agranulocytosis remained stable with 6 cases per year throughout the study period. Antimicrobials (22.8%), thyroid antagonists (17.5%), nonsteroidal anti-inflammatory agents (12.3%), and antiplatelet agents (12.3%) were the most common offenders (Table 1).