RT Journal
A1 Angelo S, Nardino RJ
T1 Comparing 5-mg and 10-mg warfarin loading doses: Are the groups similar?
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1999
FD July 26
VO 159
IS 14
SP 1624
OP 1624
DO 
UL http://dx.doi.org/
AB 
It is well known that liver function, nutritional status, and certain foods and medications can all have major effects on the pharmacokinetics and pharmacodynamics of warfarin.2- 3 It seems imperative, therefore, that Crowther and colleagues include information regarding these factors in their article, especially given the small number of subjects in the trial. Without this information, there is concern that the 2 groups could have been different, invalidating the results.