RT Journal
A1 Knudsen JF, Friedman B, Chen M, Goldwasser JE
T1 A surfeit of serotonin: Sumatriptan and serotonergic antidepressants
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1999
FD May 24
VO 159
IS 10
SP 1141
OP 1142
DO 
UL http://dx.doi.org/
AB 
Schwartz raises an important issue, namely, what is the potential for pharmacodynamic interactions when drugs such as fluoxetine, an SSRI, is coadministered with other drugs known to affect neurotransmission, for example, sumatriptan? Such drugs may alter serotonin neurotransmission by different mechanisms of action. These include inhibition of serotonin reuptake or metabolism, increased synthesis or release, and direct stimulation of serotonin receptors. Sumatriptan, the first of the class of so-called triptans to be marketed, and the "new triptans" such as naratriptan, zolmitriptan, and rizatriptan are included in the last category.